I use a 192 and love it on my Win 10 system. Does the job and then some.

kfwdrums wroteI just started using the studio 192 yesterday with my mac mini and EL capitan and I noticed the same thing. I'm using the latest drivers and firmware. I thought it was just with the spdif output because when I switch to a different output it would sometimes play sound. I love the presonus products and would love to continue using them. Hope you guy's can work this out and I'll keep you posted on anything I find. I just wouldn't want this to happen with a client in the room. Thanks for a great produce otherwise.
P.s is there a recommended settings list for setting up the computer like pro tools has, i suspect its probably similar, like no wifi,bluetooth,etc etc
Thanks,
Karl

UPDATE 2023, I've been using the studio 192 and dp 88 with a 2012 Mac Mini for the past 3-4 years and its been working great. I'm using it to record drums and full bands etc. the UC software is solid. I've also been using it with S1 Ver4.6 and it integrates very well.
Also the ipad apps are very handy to control.
Hope this helps anyone looking into using this set up.
Karl

Bbd wroteI use a 192 and love it on my Win 10 system. Does the job and then some.

Totally agree with you. - My Studio 192 rack mount has been powered on CONTINUALLY for 6 years straight (yes, you read that correctly) and has not given me a minute's worth of problems. This thing is GOLDEN!! If you can scarf one up on eBay...DO IT!!!