Some things: It would be helpful to know your specs (usually people put them in their signature) , particularly what OS you use, the version of S1 and what plugs you experience this with.
I only have a couple of VST3 plugs and as far as I know they work ok with 4.6.2 and 5.2.1
Are your transport controls sending key commands instead of actual MMC?
Some plugins can take over keyboard focus.
Project engineer by day, sound connoisseur by night.
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