I do really like the SLIII 16R. Really, I do. But right now I could throw the whole thing, rack and all, and the brand new Win10 laptop I bought for it, in the dumpster and set it on fire.

I've got the Fat Channel modules installed on the 16R.

I've got the Fat Channel plugins in Studio One 5.

Same plugins on both.

Using the WDM audio device = no problem.

When I set the Audio Device to the 16R so I can play back recorded tracks in Studio One through the 16R, and into the P.A., the "fun" begins (where "fun" is an acronym for effed-up nonsense).

When the 16R is connected to Studio One 5, I can only load ONE Fat Channel preset in Studio One, and that single preset is applied to all channels in Studio One. If I change the preset on another channel, all channels get that preset.
In the 16R itself, each channel has its own preset like it should.

When I use Windows Audio, I can set individual Fat Channel presets on each track in Studio One. Hence, no problem, other than poor audio as is to be expected.

But when I'm using the 16R as the audio device, I only get ONE Fat Channel preset across all 16 channels in Studio One, even if I start in Windows Audio (and everything set right) and switch to the 16R, and it's driving me up the monkey forking wall!