[Edited to add complete list of FX plugins.]

I've used Studio One very lightly over the past couple months, but started a simple project just after installing the 4.6.1 update. Now I experience lockups on every session. There's so frequent, I haven't had the opportunity for a clean shutdown since starting this project.

* The project is a simple comparison of drum mic placements, so just a few Gates, ProEQ, Compressor, Mixtools, Dual Pan, Binaural Pan, and Room Reverb (set to Quality). PreSonus FX only, no third party plugins in use.
* While working with the project, the transport freezes. It can happen during recording or playback, as soon as I press play or record, or during the playback/recording. It may be the first time I play or record, or up to 15 minutes later.
* At this point, much of the GUI is still responsive. For example, I can press stop, move the Now time, and save. However, subsequent attempts to play or record always freeze.
* In this state, Studio One cannot close gracefully. When I try to close, the GUI becomes unresponsive. Task Manager shows the app consuming 100% of one CPU. I've left it in this state for tens of minutes and it never exits.
* The only way to close Studio One in this state is to End Task in Task Manager. I can then reopen it and start the process again.

Since I wasn't using Studio One much over the holidays, I can't say that the 4.6.1 update specifically caused this behavior. There's probably been a Windows update or two since I used the app daily. I do know that the audio drivers (for Delta 1010) haven't changed.

Looking over the various 4.6.1 threads, I don't see anyone similar experiences. So I'd appreciate some advice on next steps for diagnosis to avoid just flailing. Thanks!